A healthy lifestyle pattern has been defined as never or past smoking (pack-years <5), no or moderate alcohol drinking (≤1 drink/d for women, ≤2 drinks/d for men), BMI of at least 18.5 but lower than 27.5, and weekly aerobic physical activity of at least 75 vigorous-intensity or 150 moderate-intensity minutes. Research on a very large sample (89 571 women and 46 339 men) proved that substantial cancer burden may be prevented through lifestyle modification (link: https://oncology.jamanetwork.com/article.aspx?articleid=2522371). Additional studies seem to prove that single factors such as BMI (link: https://oncology.jamanetwork.com/article.aspx?articleid=2522371) and physical exercise (link: http://link.springer.com/article/10.1007/s00520-015-2953-9) are effective tools in primary prevention of cancer, and in management of symptoms such as cancer related fatigue. From a psycho-oncological point of view, we may consider psychological health as a component of a mind-body approach to wellbeing. For example, studies on a large sample highlight that a past history of depression is a predictor of poorer overall survival in breast (link: http://onlinelibrary.wiley.com/enhanced/doi/10.1002/pon.4037), neck and head (link: http://onlinelibrary.wiley.com/doi/10.1002/cncr.29693/abstract) cancer patients.